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AFM was invented in 1985 by IBM scientists Gerd Binnig, Calvin Forrest Quate (19232019), and Christoph Gerber, who reported a development of a new type of microscope, which, being a combination of the principles of the scanning tunneling microscope [STM that was invented in 1981 by Gerd Binnig, Heinrich Rohrer (19332013), Christoph Gerber, and Edi Weibel ( Biomedical applications of AFM, which can operate in ambient air, high vacuum, and liquid environments, are centered at topographic imaging [e.g., it can resolve DNA double helix (Mou et al., 1995) or probe structure and dynamics of nucleosomes (Stumme-Diers et al., 2019), or visualize and provide topological information about amyloid fibrils (Lutter et al., 2020

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It is found naturally in human plasma, saliva, and urine

Spitzoid melanoma on the leg of a boy aged 10 years an amelanotic, nodular lesion that lacks traditional ABCDE diagnostic criteria Figures 3B and 3C courtesy of Professor Pascale Guitera Pigmented epithelioid melanocytomas Pigmented epithelioid melanocytomas (PEMs) most commonly arise in children, adolescents and young adults

0.75% (w/v) NaCl (i.e., 0.75 g/dl)